Notice this is the Cardinals 97th season. That is because they're an original team of the NFL, which is in it's 97th season.
The Bills being at 393 wins is very interesting, especially in light of the significance of 39 and 93 to New York.
9/25/2016 = 9+25+20+16 = 70 (Giants = 70)
9/25/2016 = 9+25+(2+0+1+6) = 43
9/25/2016 = 9+2+5+2+0+1+6 = 25
9/25/16 = 9+25+16 = 50
September 25 is the day that leaves 97-days left in the year, and this is the 97th season of the NFL. Eli Manning came into the season with 97-regular season wins.
Arizona Cardinals = 75/84/165 (Arizona = 39/84) (Cardinals = 36/45/81)
Buffalo Bills = 45/54/117 (Buffalo = 27/63) (Bills = 18/27/54) (*New York = 39)
The two teams have played 10 times, and the Bills have won 6 and lost 4. If the Bills win, they'll be 7-4, if they lose, they'll be 6-5. At the same time, if the Cardinals lose, they'll be 4-7, and last week they won 40-7, for a combined 47-points, that special NFL number.
The Bills are 3-1 against the Cardinals since the name change to Arizona Cardinals. The only loss came in Arizona.
The starting QB of the Cardinals, Carson Palmer, this game comes 93-days before his 37th birthday.
93 is a big number in New York.
Carson Palmer is playing for his 85th regular season win, and 86th win all-time.
The game also comes 8-days before the Cardinals head coach's 64th birthday.
10/3/1952 = 10+3+19+52 = 84 (Arizona = 84) (Arizona Cardinals = 84)
There are some parallels between Carson Palmer and the Bills, as well as Bruce Arians and New York, where the game is to be played. Of course New York and Arizona are the only two states with '39' gematria.
He will be attempting to earn his 36th win as the coach of the Cardinals. Cardinals = 36
On the other side of the ball, Tyrod Taylor is starting in his 16th game as QB, trying to even his record at 8-8. If he loses, he will be 7-9.
If the Cardinals win, they'll be 5-6 against the Bills, and in part, thanks to Tyrod Taylor.
If Taylor makes 17-completions in the game, he'll be at '311'. Bill = 17
This game will come in a span of 54-days from Taylor's birthday. Bills = 54; Buffalo Bills = 54
The coach, Rex Ryan, is looking for his 55th career win, and his 9th with the Bills. It is the first time in his career he has been 0-2 to start a season. If he loses, he could be fired, with a career '54' wins having coached the Jets and the Bills.
Here is a USA Today article about him being on the hot seat, the hottest seat.
I have not decided who will win this game. I do like the narrative of Rex Ryan being fired with 54-career wins as the coach of the Bills and the Jets, so it makes me lean towards Cardinals, even though historically they have struggled in this series.